Department Colloquium
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Speaker:
Dr Jin Zhou Department of Mathematics and Computer Science Northern Michigan University Time and Place: 3:30 p.m., Friday, January 18, 2008, 14 Allen Title: Composite MicroRNA Targets Prediction and Expression Analysis Abstract: MicroRNAs are noncoding RNAs whose role is to repress translation by binding to mRNA targets. There are computational algorithms for microRNA target predictions, but their results vary. We have systematically studied the prediction algorithms through the use of similarity measures and composite statistics. A cross-entropy Monte Carlo method is explored for solving the rank aggregation problem. We have also measured expression levels of microRNAs in the NCI-60 cancer cell lines and investigated the ability of microRNA expression levels to predict tissue of origin. Refreshments: 3:00-3:30 p.m., 467 Allen |